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Idiopathic autoimmune hemolytic anemia

Definition

Idiopathic autoimmune hemolytic anemia is a drop in the number of red blood cells due to increased destruction by the body's defense (immune) system.

Alternative Names

Autoimmune hemolytic anemia; Anemia - idiopathic autoimmune hemolytic

Causes

Idiopathic autoimmune hemolytic anemia is an acquired disease that occurs when antibodies form against a person's own red blood cells. In the idiopathic form of this disease, the cause is unknown.

Idiopathic autoimmune hemolytic anemia accounts for one-half of all immune hemolytic anemias.

There are other types of immune hemolytic anemias in which the cause may result from an underlying disease or medication. The disease may start quickly and be very serious.

Risk factors are not known.

Symptoms

Exams and Tests

Direct Coombs' test
Hemoglobin in the urine
Indirect Coombs' test
Red blood cell count and serum hemoglobin
Reticulocyte count
Serum bilirubin levels
Serum haptoglobin

Treatment

This version of the Encyclopedia has no treatment information. Please discuss any and all treatment options for your condition with your healthcare professional.

Outlook (Prognosis)

Adults may have chronic, relapsing disease, but in children the anemia is usually short-lived.

Possible Complications

Infection (from treatment)
Severe anemia

When to Contact a Medical Professional

Call your health care provider if you notice symptoms of anemia.

Prevention

There is no known prevention for idiopathic autoimmune hemolytic anemia, because the cause is unknown.

References

Schwartz RS. Autoimmune and intravascular hemolytic anemias. In: Goldman L, Ausiello D. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 164.

Review Date: 11/23/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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