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Hairy cell leukemia

Definition

Hairy cell leukemia (HCL) is a rare cancer of the blood. It affects B cells, a type of white blood cell (lymphocyte).

Alternative Names

Leukemic reticuloendotheliosis; HCL; Leukemia - hairy cell

Causes

HCL is caused by the abnormal growth of B cells. The cells can look "hairy" under the microscope because they have fine projections coming from their surface.

HCL can lead to low numbers of normal blood cells.

The cause of this disease is unknown. It affects men more often than women. The average age of onset is 55. Hairy cell leukemia is rare.

Symptoms

Easy bruising or bleeding
Excessive sweating (especially at night)
Fatigue
Feeling full after eating only a small amount
Recurrent infections and fevers
Swollen lymph glands
Weakness
Weight loss

Exams and Tests

During a physical exam, the doctor may be able to feel a swollen spleen or liver. An abdominal CT scan may be done to confirm this swelling.

A complete blood count shows low levels of white and red blood cells as well as platelets.

Blood tests and a bone marrow biopsy can detect hairy cells. Flow cytometry or a test called TRAP can confirm the cancer diagnosis.

Treatment

This version of the Encyclopedia has no treatment information. Please discuss any and all treatment options for your condition with your healthcare professional.

Outlook (Prognosis)

Newer chemotherapy treatments have greatly improved the survival of patients with hairy cell leukemia. Most patients with hairy cell leukemia can expect to live 10 years or longer with the disease.

Possible Complications

The low blood counts caused by hairy cell leukemia can lead to infections, fatigue, and excessive bleeding.

When to Contact a Medical Professional

Call your health care provider if you have significant bleeding. Also call if you have signs of infection, such as a persistent fever, cough, or general ill feeling.

Prevention

There is no known way to prevent this disease.

References

Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: pp.1403-1404.

Review Date: 7/11/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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