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Hand-Schüller-Christian disease
(hand shūl´әr kris´chәn)
a chronic, slowly progressive variant of the multifocal form of Langerhans cell histiocytosis, characterized by granulomatous lesions with histiocyte proliferation involving mainly the bones and skin; it affects children
and young adults. The three classic symptoms are softened areas of the skull and other flat bones, exophthalmos, and diabetes insipidus, although all three symptoms are rarely found in one patient. Many patients develop otitis, skin lesions like those of seborrheic dermatitis, or xanthomas.
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