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transposition (trans″po-zĭ´shәn) any of various congenital anomalies in which organs are displaced to the opposite side from normal. the operation of carrying a tissue flap from one situation to another without severing its connection entirely until it is united at its new location. the exchange of position of two atoms within a molecule. movement of genetic information from one locus to another. transposition of great vessels
a congenital heart defect in which the position of the chief blood vessels of the heart is reversed, so that the aorta arises from the right ventricle instead of the left and the pulmonary artery emerges from the left ventricle rather than from the right. The result is that oxygen-poor blood returning from the systemic
circulation to the right side of the heart gets pumped back into the general circulation instead of being transported to the
lungs, and oxygen-rich blood flows aimlessly to and from the lungs. For a person to survive with this condition, there must
be some way for mixing of blood between the two circulations, such as through a ventricular septal defect.
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