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low-density lipoprotein(LDL) a class of lipoproteins responsible for transport of cholesterol to tissues other than the liver. It is formed in the circulation when very-low-density lipoproteins are degraded first to intermediate-density lipoproteins and then to LDL. High levels of cholesterol in the blood mean increased risk of ischemic heart disease. Because low-density lipoproteins carry most of the cholesterol, high serum levels of them mean a higher risk for heart disease.
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