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cytotoxic T lymphocytes differentiated T lymphocytes, marked by CD4 and CD8 antigens, able to recognize and lyse target cells bearing specific antigens recognized by their antigen receptors. The cytotoxic activity requires firm binding of the lymphocyte to the target cell to produce holes in its plasma membrane with loss of its cellular contents and osmotic lysis. These lymphocytes are important in graft rejection and killing of tumor cells and virus-infected host cells. Called also killer or killer T cells.
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