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mucolipidosis II
a rapidly progressing disease of young children, histologically characterized by abnormal fibroblasts containing a large number
of dark inclusions which fill the central part of the cytoplasm except for the juxtanuclear zone (I-cells), and clinically
by severe growth impairment, minimal hepatic enlargement, extreme mental and motor retardation, and clear corneas; inherited
as an autosomal recessive trait, it is due to deficiency of multiple lysosomal hydrolases. Called also I-cell disease.
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