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gluconeogenesis (gloo″ko-ne″o-jenīә-sis) the synthesis of glucose from noncarbohydrate sources, such as amino acids or glycerol. It occurs primarily in the liver and kidneys whenever the supply of carbohydrates is insufficient to meet the body's energy needs. Gluconeogenesis is stimulated by cortisol and other glucocorticoids and by the thyroid hormone thyroxine.
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