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graft-versus-host disease(GVH disease)  graft-versus-host reaction  a condition that occurs when immunologically competent cells or their precursors are transplanted into an immunocompromised recipient (host) that is not histocompatible with the donor. Because the host is immunocompromised, the graft is not rejected. Immunocompetent T lymphocytes derived from the donor tissue recognize the recipient's tissue as foreign or nonself and react with it, producing clinical manifestations including edema, erythema, ulceration, loss of hair, and heart and joint lesions similar to those of connective tissue disorders. This condition is a frequent complication of bone marrow transplantation. Tissue typing and HLA antigen matching of the donor and recipient reduce the possibility of graft-versus-host disease.




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