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Simmonds disease (simĀ“ondz)   panhypopituitarism in which cachexia is a prominent feature; it usually follows destruction of the pituitary gland by surgery, infection, injury, or tumor, but may also occur in women after difficult labor in childbirth. Symptoms, which vary in intensity, include extreme weight loss, weakness, pallor, dry yellowish skin, a slow pulse, hypotension, and atrophy of the genitalia and breasts; if untreated, the condition may progress to premature senile dementia. Called also pituitary cachexia.




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