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streptozocin (strep″to-zo´sin) an antitumor antibiotic derived from Streptomyces achromogenes, now produced synthetically. It acts as an alkylating agent to inhibit DNA synthesis, and also as an inhibitor of enzymes involved in gluconeogenesis; used primarily for treatment of islet cell tumors, as well as other endocrine tumors such as gastrinomas associated with Zollinger-Ellison syndrome and glucagonomas.
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