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major depressive episode  a period of daily and day-long depressed mood or loss of interest or pleasure in virtually all activities. Also present is some combination of altered appetite, weight, or sleep patterns, psychomotor agitation or retardation, difficulty thinking or concentrating, lack of energy and fatigue, feelings of worthlessness, self-reproach, or inappropriate guilt, recurrent thoughts of death or suicide, and plans or attempts to commit suicide. See also bipolar disorders and mood disorders.




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