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cephalosporin (sef″ә-lo-sporŽin) any of a large group of broad-spectrum antibiotics from Acremonium (formerly Cephalosporium), a genus of soil-inhabiting fungi. Cephalosporins are similar in structure and antimicrobial action to penicillin. The cephalosporins have been classified by “generations” according to general features of antimicrobial activity, with successive generations having increasing activity against gram-negative organisms and decreasing activity against gram-positive organisms.
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