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Hodgkin disease (hoj´kin) Hodgkin lymphoma a form of malignant lymphoma characterized by painless, progressive enlargement of the lymph nodes, spleen, and lymphoid tissues generally. It often begins in a lymph node on the side of the neck and then spreads through the body. The first sign of the disease usually is an enlargement of lymph nodes in the cervical, axillary, or inguinal chains. Severe itching is often an early symptom; this may be followed by fever, night sweats, and weight loss. As the disease progresses, it spreads through the lymphatic system to involve lymph nodes elsewhere in the body as well as the spleen, liver, and bone marrow. The lymph nodes, spleen, and liver may swell, obstruct other organs, and cause coughing, breathlessness, or enlargement of the abdomen. There may be changes in blood components to cause the body to be less able to combat infections. Hodgkin disease, lymphocyte depletion type
a type of Hodgkin disease characterized by a low number of lymphocytes and an abundance of Reed-Sternberg cells with fibrosis;
it is the most aggressive of the three diffuse types of Hodgkin disease. Called also Hodgkin sarcoma. Hodgkin disease, lymphocyte predominance type
a type of Hodgkin disease characterized by a diffuse to slightly nodular infiltrate with abundant mature lymphocytes and varying
numbers of benign histiocytes; there are few Reed-Sternberg cells and the degree of malignancy is low. Most patients are males
under age 35. Called also paragranuloma. Hodgkin disease, mixed cellularity type
a type of Hodgkin disease intermediate between the lymphocyte predominance and lymphocyte depletion types; Reed-Sternberg
cells are plentiful and there are more inflammatory cells, such as eosinophils and plasma cells, than in the lymphocyte predominance
type. Hodgkin disease, nodular sclerosis type
a type of Hodgkin disease in which Reed-Sternberg cells are in the form of lacunar cells and bands of collagen divide the
lymphoid tissue into nodules; there are varying numbers of lymphocytes and inflammatory cells such as eosinophils and plasma
cells. This type is most common in young women and often has a low grade of malignancy.
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